Rapid communication: a BstXI polymorphism in the porcine matrix metalloproteinase 1 (MMP-1) gene locus.
نویسندگان
چکیده
1This project is supported by grants from the National Natural Science Foundation of China; Ministry of Agriculture, China, and Sino-German Agricultural Cooperation Program. 2Present address: Centre for Genetic Improvement of Livestock, Dept. of Anim. and Poult. Sci., Univ. of Guelph, Guelph, Ontario N1G 2W1 Canada. 3To whom correspondence should be addressed (phone: 08161 71 3746; E-mail: [email protected]). Received August 17, 1998. Accepted November 15, 1998. 1999 American Society of Animal Science. All rights reserved. Figure 1. PCR-RFLP patterns of the porcine MMP1 gene. Lanes 1 and 2: homozygotes BstXI−/BstXI− animals, 374 bp; lanes 3 to 6: homozygotes BstXI+/ BstXI+ animals, 249+125 bp; lane 7: heterozygote BstXI−/BstXI+ animal, 374+249+125 bp; lane 8: control PCR product, 374 bp; lane 9: 123-bp DNA ladder (BRL Life Technologies, Gaithersburg, MD). Rapid Communication: A BstXI Polymorphism in the Porcine Matrix Metalloproteinase 1 (MMP-1) Gene Locus1
منابع مشابه
Gene Polymorphism of Matrix Metalloproteinase 9 in Asthenozoospermic Male Subjects
Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...
متن کاملThe Role of Matrix Metalloproteinase-3 Functional 5A/6A Promoter Polymorphism in Tumor Cell Progression and Metastasis of Breast Cancer
In the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (MMP) genes. Single nucleotide polymorphisms in the promoter region of MMP genes are important for MMP expression. A common adenine deletion polymorphism (5A) at position -1171 of the MMP-3 gene promoter (5´-AAAAAACCAT-3´ change to 5´-AAAAACCAT-3´) facilitates transcriptional factor binding and MMP-3 promoter acti...
متن کاملبررسی پلیمورفیسم ماتریکس متالوپروتئیناز-1 و استعداد ابتلا به سرطان مثانه
Introduction: Matrix metalloproteinase-1 with the destruction of the basement membrane and extracellular matrix not only facilitates the spread of cancer cells, but also with the release of growth factors and angiogenesis plays a key role in cancer cell survival and nutrition. The purpose of this study was to recognize the relation between the polymorphism of Matrix metalloproteinase-1 gene and...
متن کاملThe Effect of Adiponectin on Matrix Metalloproteinase-9 (MMP-9) in Vascular Smooth Muscle Cells
Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...
متن کاملAnalyzing the association of MMP-3 promoter polymorphism and its serum concentration with the outcome of in vitro fertilization and embryo transfer
This study aimed to investigate the polymorphism of matrix metalloproteinase -3 (MMP-3) gene and its expression in the serum of infertile female patients received in vitro fertilization and embryo transfer (IVF-ET). To do so, 100 women with unsuccessful IVF-ET (IVF–) and 100 women with successful IVF-ET procedure and clinical pregnancy (IVF+) were included. Genetic polymorphism and serum concen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of animal science
دوره 77 4 شماره
صفحات -
تاریخ انتشار 1999